Establishment of Mathematic Model of the Extraction Kinetics of the Components of Chinese Complex Prescription and the Effect of Particle Size on the Concentration of Catalpol in Rehmanniae Decoction of Liuwei Dihuang Decoction
- VernacularTitle:中药(复方)成分提取动力学数学模型建立及粒径对六味地黄汤中梓醇浓度的影响
- Author:
Hongyu LIU
- Publication Type:Journal Article
- Keywords:
Extraction kinetics;
Mathematic model;
Closed system;
Components of Chinese complex prescription;
Particle size;
Liuwei dihuang decoction;
Catalpol
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE:To establish a mathematical model for the dissolution kinetics of the components of the closed diffusion system of Chinese complex prescription,and to study and analyze the parameters of the extraction kinetics of catalpol,an active component in rehmanniae decoction of Liuwei dihuang decoction. METHDOS:The mathematic modeling method was applied to the extraction process of the traditional Chinese medicine; the mathematic model of the extraction process of the Chinese medicine was established based on the extraction principle and Fick law,and the function expression was derived from the fitting of the mathematic model and analysis of parameters,then the model was applied to the study of the kinetic parameters of the catalpol in rehmanniae decoction of Liuwei dihuang decoction. RESULTS:The analytic solution of the dissolution concentration of components consisting of 3 e in exponential form and the analytical method of parameters were obtained in this study. The optimal grain size of the herbal medicine was 60 meshes.Under this condition,the maximal peak time(tmax)of catalpol was 195.1 min;the peak concentration(Cmax) was 0.012 23 mg?mL-1;the maximal extraction rate(P) was 72.95%,and the loss rate(D) was 7.62%. CONCLUSION:The dissolution of the components of the closed soluble diffusion system of Chinese complex prescription fitted linear kinetic mathematical model,and the parameters can be derived from the expression relation of the dissolution concentration.
