Determination of the Dissolution of Zaltoprofen Tablets
- VernacularTitle:扎托洛芬片溶出度测定
- Author:
Mei XUE
- Publication Type:Journal Article
- Keywords:
Zaltoprofen tablets;
Dissolution;
UV spectrophotometry
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for determining the dissolution of Zaltoprofen tablets.METHODS:The content determination was conducted by UV spectrophotometry with detection wavelength of 330 nm.The paddle method was applied to calculate dissolution with phosphoric acid buffer solution (pH 6.8) as solvent and rotation speed of 100 r?min-1.After 30 min the sample was collected.RESULTS:The method showed a good linear relationship in the range of 2.5～30 ?g?mL-1(r=0.999 9).The average recovery was 100.36% (RSD=0.54%).The dissolutions of 3 batches of samples were all above 80%.CONCLUSION:The method is simple,accurate,and reliable for the determination of the dissolution of Zaltoprofen tablets.
