Expressions of focal adhesion kinase and matrix metalloproteinase-9 in pituitary adenomas
- VernacularTitle:黏着斑激酶与基质金属蛋白酶9在垂体腺瘤中的表达
- Author:
Chao CHENG
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
Pituitary Neoplasms;
Adenoma;
Focal Adhesion Protein-Tyrosine Kinases;
Matrix Metalloproteinase 9;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the expression and its significance of focal adhesion kinase(FAK)and matrix metalloproteinase 9(MMP-9)in the pituitary adenomas. METHODS The expressions of FAK and MMP-9 were determined by immunohistochemical technique in 50 pituitary adenoma tissues samples obtained during operation, including 27 invasive pituitary adenomas and 23 non-invasive pituitary adenomas. The relationship of FAK and MMP-9 expression with tumor invasiveness were analyzed. RESULTS The expression of FAK and MMP-9 in the invasive pituitary adenomas were significantly higher than those in the non-invasive pituitary adenomas(P
