Esomeprazole versus Lansoprazole in the Treatment of Reflux Esophagitis
- VernacularTitle:埃索美拉唑与兰索拉唑治疗反流性食管炎的疗效比较
- Author:
Xiaoli MA
- Publication Type:Journal Article
- Keywords:
Esomeprazole;
Lansoprazole;
Reflux esophagitis
- From:
China Pharmacy
2007;0(35):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy of esomeprazole vs.lansoprazole in the treatment of patients with reflux esophagitis (RE).METHODS:A total of 120 patients with RE were randomly assigned to receive either esomeprazole (20 mg n&m,treatment group) or lansoprazole (30 mg n&m,control group) for 8 weeks.The symptomatic scores including heartburn,retrosternal pain and acid regurgitation,and gastroscopic curative efficacy at 4 and 8 weeks were obtained for the evaluation of clinical efficacy.RESULTS:In the treatment group at 4 and 8 weeks after treatment,the total effective rates in improvement of clinical symptoms were 78.1% and 87.5%,respectively,and the total effective rates of gastroscopic curative efficacy were 87.5% and 93.8%,respectively;while in the control group at 4 and 8 weeks,the total effective rates in improvement of clinical symptoms were 60.7% and 73.2%,respectively,and the total effective rates in gastroscopic curative efficacy were 73.2% and 80.4%,respectively,showing statistical differences in total effective rates between esomeprazole and lansoprazole(P
