Rapid Assessment of Respiratory Drug Delivery Efficacy with Small Animal Imaging Technology
- VernacularTitle:利用小动物活体成像技术快速评价呼吸道给药效果
- Author:
Yina PAN
;
Yuhong XU
- Publication Type:Journal Article
- Keywords:
Small animal imaging;
Respiratory drug delivery;
Aerosol;
Fluorescent distribution;
Evaluation
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the distribution of fluorescent material in the respiratory tract of animals with the use of small animal imaging technology to quickly evaluate the effects of respiratory drug delivery. METHODS: The Kunming mice in the experimental group were administered with Cy5.5 fluorescent-labeled aerosol,meanwhile,a positive control group was set up by injecting same amount of compound anhydrous diethyl ether solution via tracheal incubation,with negative control group inhaled the same amount of non-Cy5.5 fluorescently-labeled aerosol. The fluorescent distribution of the aerosolized particles in the respiratory tract was observed. RESULTS: Fluorescently-labeled aerosol was observed in both the experimental group and the positive control group but not in negative control group. CONCLUSION: The small animal imaging technology is expected to be used as a rapid and effective method for evaluating the efficacy of respiratory drug delivery.
