Effects of Shenqi Fuzheng Injection on the Expression of MMP-3 and TIMP-1 in Rats with Congestive Heart Failure
- VernacularTitle:参芪扶正注射液对心力衰竭模型大鼠心肌MMP-3、TIMP-1的作用研究
- Author:
Jinshui CHEN
;
Tianmin WU
;
Liqin CHEN
- Publication Type:Journal Article
- Keywords:
Shenqi Fuzheng injection;
Congestive heart failure;
MMP-3;
TIMP-1
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of Shenqi Fuzheng injection on the expression of MMP-3 and TIMP-1 in congestive heart failure model rats.METHODS: The experimental rats were randomly divided into 6 groups,i.e.normal group,model group,captopril(10 mg?kg-1)group,Shenqi Fuzheng injection low dosage(2 mL)group,Shenqi Fuzheng injection medium dosage(4 mL)group,and Shenqi Fuzheng injection high dosage(6 mL)group.All except the normal group were intraperitoneally injected with adriamycin on the first experimental day.After drug intervention for 8 weeks,the rats were anesthetized and sacrificed,with heart specimen sampled rapidly for pathological examination and semi-quantitative analysis of myocardial MMP-3 and TIMP-1 mRNA by RT-PCR method.RESULTS:In the model group compared with the normal group,MMP-3 mRNA were significantly increased(P
