Possibility of the acellular bony microtubule used to construct tissue engineering ossicular prosthesis
- VernacularTitle:脱细胞骨微管用于构建组织工程化听骨赝复物的可行性
- Author:
Xuesheng LI
;
Jianjun SUN
;
Cheng XU
- Publication Type:Journal Article
- Keywords:
Tissue Engineering;
Ossicular Prothesis;
Bone Morphogenetic Proteins;
Microtubules
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the possibility of acellular bony microtubule used to construct tissue engineering ossicular prosthesis. METHODS To prepare the acellular bony microtubule, observe the change of its histocompatibility and biomechanics. The acellular bony microtubule carried with collagen/ BMP-2 was implanted into the middle ear of the animals. The ectopic osteogenesis was observed. RESULTS The acellular bony microtubule has good histocompatibility. There wasn’t significant change about biomechanics. After carried with collagen/BMP-2, the bony microtubule can induce osteogenesis in the animal’s middle ear. CONCLUSION The acellular bony microtubule carried with collagen/BMP-2 has the possibility to be used to construct tissue engineering ossicular prosthesis.
