Risk Factors of Antibiotic-associated Colitis:A Clinical Study
- VernacularTitle:引起抗生素相关性肠炎危险因素的临床研究
- Author:
Xuemei LI
;
Lijuan YANG
;
Ping ZHANG
- Publication Type:Journal Article
- Keywords:
Antibiotic-associated diarrhea;
Risk factors;
Logistic model
- From:
China Pharmacy
2007;0(32):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the relevant risk factors of antibiotic-associated colitis (AAC) and provide objective basis for formulating measures to prevent AAC.METHODS:Of the total of 3 520 patients who received antibiotics in our hospital during 2007～2008,those with AAC were assigned to trial group and those without AAC to control group.The factors that might influence AAC were subjected to single-factor analysis and Logistic regression analysis.RESULTS:Of the total 3 520 patients,AAC was noted in 190 patients (5.4%).Through single-factor analysis,10 factors were found to be associated with AAC;and through non-conditional Logistic model analysis,the following 6 major risk factors were found to be associated with AAC,i.e.,older age,fasting,severe cases,using numerous kinds of antibiotics,long-term use of antibiotics and use of antacid.CONCLUSION:AAC are associated with multiple factors,but its incidence can be prevented or reduced through rational use of antibiotics,monitoring on elder cases,supplement of probiotics,early enteral nutrition and food intake,control of the medication duration of antacids,reduction of invasive operation for the severe cases and avoiding frequent change of antibiotics,etc.
