Formulation Optimization of Isosorbide Mononitrate Sustained-release Tablets by Mixture Design
- VernacularTitle:混料设计法优化单硝酸异山梨酯缓释片处方
- Author:
Xiaojing GUO
;
Kaiyong TANG
;
Qingwu ZHOU
- Publication Type:Journal Article
- Keywords:
Isosorbide mononitrate;
Sustained-release tablet;
Mixture design;
Formulation optimization
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the application of mixture design in the design of formulation.METHODS:Isosorbide mononitrate (ISMN) was used as model drug,and the formulation of ISMN sustained-release tablet was optimized by the mixture design.The optimized ISMN sustained-release tablets were compared with the ISMN sustained-release tablets in market in respect of the release rate in vitro.RESULTS:The comparison between the validating value and the target value of the optimized sample showed a similarity factor(f2) of 86.56,and there were no differences between the optimized sample and that in market in respect of the drug release in vitro.CONCLUSION:The mixture design is applicable for the optimization of formulation and it can be used to predict the drug release in vitro.
