Optimization of the Preparation Technology of Baicalein Sustained Release Microspheres by Central Composite Design
- VernacularTitle:星点设计法优化黄芩素缓释微球制备工艺
- Author:
Lijun YU
- Publication Type:Journal Article
- Keywords:
Baicalein;
Sustained release microspheres;
Central composite design;
Preparation technology
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the preparation technology of Baicalein sustained release microspheres.METHODS:The microspheres containing baicalein were prepared using solvent evaporation technique.Multiple linear regression equation and quadratic polynomial equation were fitted respectively with the mass ratio of the matrix materials,sodium dodecyl sulfate(SDS)concentration in water phase and drug content as independent variables,and with the accumulative drug release percentage at 2,12 and 24 h(Y1,Y2,Y3)as dependent variables.RESULTS:The baicalein sustained release microspheres prepared in accordance with the above technology were spherical and even.The optimized technical conditions were as follows:the drug content was 25%;the ratio of the matrix materials was 3.5;SDS concentration was 0.08%;Y1,Y2 and Y3 were 21.05%,55.70% and 87.75%,respectively.All the three equations fitted using quadratic polynomial equations achieved good fitting results.CONCLUSION:Central composite design is convenient to use and it has satisfactory predictability thus deserving popularization.
