Effects of Yixinshu Capsule on Cardiac Function and Plasma Levels of Ang Ⅱ and TNF-? in Patients with Chronic Cardiac Failure
- VernacularTitle:益心舒胶囊对慢性心力衰竭患者心功能及Ang Ⅱ和TNF-?的影响研究
- Author:
Chuanyu LIU
;
Jianhong TANG
;
Han SU
;
Jianyi ZHANG
- Publication Type:Journal Article
- Keywords:
Yixinshu capsule;
Chronic heart failure;
Cardiac function;
AngiotrnsionⅡ;
Tumor necrosis factor-?
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the curative efficacy of Yixinshu capsule(YXSC)for patients with chronic heart failure(CHF)and its effects on plasma levels of angiotrnsionⅡ(Ang Ⅱ)and tumor necrosis factor-alpha(TNF-?).MET-HODS:60 patients with CHF were randomly assigned to either treatment group(n=30)or control group(n=30):the control group received conventional symptomatic treatment with western medicines including anti-infection therapy,relieving airway obstruction,continuous low-flow oxygen inhalation,cardiac and diuretic therapy,vasodilator,correcting acid-base imbalance and electrolyte disturbances etc;the treatment group received YXSC in combination with the above conventional symptomatic treatment.Plasma levels of AngⅡ and TNF-? in two groups before and after treatment were detected;and the cardiac function and the indexes of echocardiography(LVEF,A/E)of all cases were recorded in detail before and after treatment.Meanwhile,10 healthy subjects served as normal control.RESULTS:After treatment,plasma levels of AngⅡ and TNF-? in both group decreased remarkably(P
