Effect of Shugan Jianpi Formula on Proliferation/Apoptosis of Hyperplastic Tissues of Mammary Gland in Model Rats
- VernacularTitle:疏肝健脾方对模型大鼠乳腺增生组织细胞增殖/凋亡的影响
- Author:
Xiangqi LI
;
Xiangguo DANG
- Publication Type:Journal Article
- Keywords:
Shugan jianpi formula;
Hyperplasia of mammary gland;
Proliferating cell nuclear antigen;
Apoptosis;
Regulatory factors
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effect of Shugan jianpi formula on the proliferation and apoptosis of the hyperplastic tissues of mammary gland of model rats.METHODS:The rats were injected with benzestrofol and progesterone to establish mammoplasia model,meanwhile which were treated intragastrically with Shugan jianpi formula for 30 days.The degree of mammoplasia,as well as the PCNA(proliferating cell nuclear antigen),the apoptotic related regulating factors such as Bcl-2 and Bax and the apoptotic index(AI)of the mammary gland were detected.RESULTS:Shugan jianpi formula inhibited the mammoplasia,down-regulated the expression levels of PCNA and Bcl-2,up-regulated the expression level of Bax and AI,inhibited the proliferation of the mammary tissues and promoted apoptosis.CONCLUSION:Shugan jianpi formula blocks or reverses the hyperplasia of mammary gland by regulating the cell proliferation/apoptosis of the hyperplastic tissues of mammary gland.
