Effect of Breviscapine on SOD Activity and Apoptosis in Rats of Cerebral Ischemia-reperfusion Injury
- VernacularTitle:灯盏花素对大鼠脑缺血再灌注损伤后SOD和细胞凋亡的影响
- Author:
Qunhua YANG
;
Xingsan TANG
- Publication Type:Journal Article
- Keywords:
Breviscapine;
Cerebral ischemia-reperfusion injury;
Superoxide dismutase(SOD);
Apoptosis
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of breviscapine on SOD(superoxide dismutase)activity and apoptosis in rats after cerebral ischemia reperfusion(I-R).METHODS:The experimental rats were divided into 5 groups:sham group,I-R group,MgSO4 group,high dose breviscapine group and low dose breviscapine group.The SOD activities in brain tissue and serum of rats and the apoptosis of brain cells were observed.RESULTS:Compared with the sham group,the model group showed significantly decreased SOD activities in both brain tissue and serum(P
