Expression of RANK-RANKl-OPG system in middle ear cholesteatoma
- VernacularTitle:破骨细胞分化因子及其相关因子在中耳胆脂瘤组织的表达
- Author:
Xiaohua CHEN
;
Zhaobing QIN
;
Wei LU
- Publication Type:Journal Article
- Keywords:
Cholesteatoma,Middle Ear;
Osteoclasts;
Child;
Adult
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of nuclear factor-kappa B ligand-receptor activator of nuclear factor-kappa B-osteoprotegerin(RANKRANKL-OPG)system on bone resorption in middle ear cholesteatoma,and the reasons why middle ear cholesteatoma in children were more aggressive. METHODS The expression of RANKL and OPG in 21 adults cholesteatoma,17 children cholesteatoma and 18 normal external meatal skin was studied with immunohistochemistry. Semiquantitative analysis was used for comparison and statistical analysis. RESULTS RANKL-positive cells and the ratio of RANKL/OPG in cholesteatoma were significantly higher than that in external meatal skin(P
