Granulocyte Macrophage Colony Stimulating Factor as an Adjunctive Therapy for Acute Myeloid Leukemia:A Systematic Evaluation
- VernacularTitle:粒细胞-巨噬细胞刺激因子辅助治疗急性骨髓性白血病的系统评价
- Author:
Bin WU
;
Ting XU
;
Jing LU
;
Le YANG
;
Yao TANG
- Publication Type:Journal Article
- Keywords:
Granulocyte macrophage colony stimulating factor;
Acute myeloid leukemia;
Systematic evaluation
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the curative efficacy of granulocyte macrophage colony stimulating factor (GM-CSF) as an adjunctive therapy for the treatment of acute myeloid leukemia (AML). METHODS: Randomized controlled trials (RCTs) of GM-CSF in the treatment of AML were retrieved from PubMed,EMBase,Cochrane Library,CBMdisc and CNKI database by computer as well as from the leukemia-related journals manually for a quality evaluation of the methodology and Meta analysis using RevMan5.0 software. RESULTS: A total of 10 RCTs were included,of which,3 RCTs were graded as A,5 as B and 2 as C. The results demonstrated that there were no significant differences of indexes among groups as complete remission (CR) rate,relapse rate,infection rate and length of hospital stay,etc. CONCLUSION: The available clinical research results showed that GM-CSF adjunctive therapy could neither increase CR rate,nor decrease the relapse rate,infection rate or length of hospital stay.
