In Vitro Antibacterial Activitey of Moxifloxacin Combined with Cefoperazone/Sulbactam Against Multidrug Resistant Bacteria
- VernacularTitle:莫西沙星与头孢哌酮/舒巴坦联用对金黄色葡萄球菌等多重耐药菌的体外抗菌效果研究
- Author:
Limeng WU
;
Dongmei LAI
;
Guanglong CHEN
- Publication Type:Journal Article
- Keywords:
Moxifloxacin;
Cefoperazone / Sulbactam;
Drug combination;
MIC;
Fractional inhibitory concentration index
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the antibiotic activity of Moxifloxacin (MFX) combined with Cefoperazone/Sulbactam (CPZ/SBT) against clinical common resistant bacteria for clinical reference of rational use of antibacterials.METHODS: The MIC of two antibiotics used alone or in combination on staphylococcus aureus,Klebsiella pneumoniae,Pseudomonas aeruginosas(50 strains,respectively)and Escherichia coli,enterobacter cloacae(20 strains,respectively)were detected respectively by Vitek-32 Model (Full Automated bacterium Detection Device) and the fractional inhibitory concentration(FIC) index was calculated. RESULTS: The combination of two antibiotics significantly reduced MIC on 190 common resistant pathogenic strains and enhanced antibiotic action. Their antibacterial action in vitro was characterized by synergism and additive action. CONCLUSION: The study can present reference for hospital treatment of infection induced by common drug-resistant bacteria.
