Association between platelet membrane glycoprotein IIb polymorphism and coronary heart disease in Han people
- VernacularTitle:汉族人血小板GPⅡb HPA-3基因多态性与冠心病的相关性研究
- Author:
Mei XUE
;
Keji CHEN
;
Huijun YIN
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Platelet membrane glycoprotein IIb;
Gene polymorphism
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the genotype distributions of HPA-3 in Han people from Beijing and Hebei province,and to study the association of the platelet glycoprotein IIb polymorphism with coronary heart disease(CHD).METHODS:Two hundred and twelve patients with coronary heart disease and 106 healthy controls were enrolled in this case-control study.The number of occlusive coronary artery was performed in all subjects.The genotypes of HPA-3 were determined by TaqMan probe technology.RESULTS:In CHD patients(older than 45 years)carriers of HPA-3b were over-represented compared with healthy controls(P
