Expression of factors related to peritoneal metastasis of gastric cancer and its relationship to prognosis
- VernacularTitle:胃癌腹膜转移与相关因素表达及预后的关系
- Author:
Jun ZHEN
;
Xu CHEN
;
Zhaoyang HAN
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
Neoplasm Metastasis,Peritoneum;
ICAM-1;
MMP-2;
TIMP-1;
p53;
Prognosis
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study molecular biology and clinicopathologic characters of peritoneal metastasis of advanced gastric cancer and their relationship to prognosis. Methods Based on the molecular biology and the clinicopathologic characters and prognosis single-factor analysis of relevant factors and risk assessment was made in 193 cases of gastric cancer.Results The younger the patient was with the earlier the time of occurrence of peritoneal metastasis of gastric cancer. There was a high expression of ICAM-1 and MMP-2,but low expression of TIMP-1 and p53 in gastric cancer patients with peritoneal metastasis.Conclusions ICAM-1,MMP-2,TIMP-1 and p53 can well predict the occurrence of metastasis and the prognosis of patients with gastric cancer,and these factors can be used for preoperative assessment of the development of metastasis of gastric cancer.
