Mechanism of Antiemetic Effect of Celecoxib on Cisplatin-induced Delayed Emesis in Rats
- VernacularTitle:塞来昔布抑制顺铂致大鼠迟发性呕吐的作用及机制研究
- Author:
Chuanxia JU
;
Wang YUE
- Publication Type:Journal Article
- Keywords:
Cisplatin;
Celecoxib;
Rat;
Emesis;
5-HT;
Tryptophan hydroxylase;
Monoamine oxidase
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the action mechanism and effect of celecoxib on cisplatin-induced delayed emesis in rats.METHODS:The rats were divided into control group,cisplatin group,and celecoxib group(cisplatin plus celecoxib).Kaolin intake in the rats after administration of corresponding drugs was observed.Levels of 5-HT and its metabolite 5-HIAA in intestinal tissues,and the activities of tryptophan hydroxylase(TPH)and monoamine oxidase(MAO)were determined,and the morphological changes of the intestinal tissues were observed.RESULTS:In cisplatin group compared with control group,the Kaolin intake increased significantly(P
