Preparation of Isoniazid-contained Drug Layer Alloy Stent and Its Dissolution in Vitro
- VernacularTitle:含异烟肼药膜型金属支架的制备及体外溶出度试验
- Author:
Xueming WANG
;
Guokun AO
;
Hanhui XIONG
- Publication Type:Journal Article
- Keywords:
Nickel-titanium alloy stent;
Dissolution;
Isoniazid
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare a nickel-titanium alloy stent coated by anti-tuberculotic isoniazid and study the dissolution of isoniazid in vitro.METHODS:The polyurethane which was used as film-former was mixed with isoniazid before being coated uniformly on the stent,then the stend was torrefied and dried so that the drug layer alloy stent was obtained.The content and accumulated dissolution in vitro of isoniazid from the stent was determined by ultraviolet spectrophotometry.RESULTS:The linear range of isoniazid was 5.0～30.0 ?g?mL-1(r=0.999 9)and its recovery rate was 99.67%(RSD=1.06%).A high accumluated dissolution rate of isoniazid was achieved,over 60% within the first 30 minutes,followed by a sustained dissolution in the following 8 h.CONCLUSION:The preparation method of the stent is simple and the quality is controllable.
