Preparation of Glycyrrhetic Acid Derivatives-Modified Norcantharidin Liposome and Study on Its Liver-targeting Property in Mice
- VernacularTitle:甘草次酸衍生物修饰去甲斑蝥素脂质体的制备及其小鼠肝靶向性实验研究
- Author:
Chao WU
;
Weiying GUO
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Glycyrrhetic acid;
Norcantharidin;
Liposome;
Preparation;
Mice;
Liver-targeting
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare glycyrrhetic acid derivatives-modified norcantharidin(NC)liposome(GDNL)and study its liver-targeting property.METHODS:Gal-GAOSt targeting molecules were synthesized to modify NC and prepare GDNL,with the parameters such as the entrapment efficiency and particle diameter,etc.investigated.Mice were enrolled to be injected with GDNL and NC water solution,respectively via vena caudalis followed by determination of NC concentration in different tissues to compute the targeting-index(TI)of GDNL in liver.RESULTS:The prepared GDNL had an entrapment efficiency of 56.29%,particle diameter of(210?20)nm and TI of 5.213 in liver.CONCLUSION:The prepared GDNL has high entrapment efficiency and remarkable liver-targeting property.
