Anti-bradyarrhythmia Efficacy of Cilostazol:An Experimental Study
- VernacularTitle:西洛他唑抗缓慢性心律失常的实验研究
- Author:
Xingman WANG
;
Liuyi DONG
- Publication Type:Journal Article
- Keywords:
Cilostazol;
Bradyarrhythmia;
Mice;
Verapamil hydrochloride;
Nicotine;
Rabbit;
His' bundle electrogram
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect and mechanism of cilostazol in experimental anti-bradyarrhythmia.MET-HODS:Bradyarrhythmia model of mice was induced using verapamil hydrochloride and nicotine,respectively.The electrocardiograms at different time and the heart rates of the model mice after intragastric administration of different dosages of cilostazol were recorded.The in vivo His' bundle electrogram(HBE)recordings in rabbits were obtained after intragastric administration of different dosage of cilostazol for detection of A-H interval and H-V interval,which were compared with control group(normal saline group).RESULTS:Verapamil hydrochloride and nicotine markedly slowed down the heart rates of mice,but cilostazol significantly sped up the heart rates in mice(P
