Preparation and in Vitro Release Characteristics of Theophylline Pulsed Suppository
- VernacularTitle:茶碱脉冲栓剂的制备及体外释药性考察
- Author:
Xiaofang LI
;
Miaozhen JIN
;
Zhuohui LIN
- Publication Type:Journal Article
- Keywords:
Theophylline;
Pulsed suppository;
Preparation;
Formulation;
In vitro drug release
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare theophylline pulsed suppository(TPS)and evaluate its in vitro release characteristics.METHODS:The formulation of TPS was optimized using single factor method taking the amount of base materials including poloxamer,CMC-Na,PEG 6000 and PEG 400 as factors with lag time of drug release and the accumulative drug release rate served as indexes.The accumulative drug release rates of the TPS prepared with different fillers(crude drug of theopylline,theopylline-PVP physical mixture,and the theopylline-PVP solid dispersion)were investigated.RESULTS:The optimal formulation was as follows:70% poloxamer,6% CMC-Na,12% PEG 6000,12% PEG 400;its lag time of in vitro drug release was about 4 hours and its accumulative drug release rate at 90 min reached more than 85%.The accumulative drug release rates of the suppository prepared with 3 different fillers were 58.8%,65.8% and 91%,respectively.CONCLUSION:The prepared TPS showed satisfactory pulsed release efficacy.
