A case of antiepileptic drug hypersensitivity syndrome by lamotrigine mimicking infectious mononucleosis and atypical Kawasaki disease.
10.3345/kjp.2009.52.3.389
- Author:
Su Jung YOO
1
;
Ihl Sung PARK
;
Eun Sook SUH
Author Information
1. Department of Pediatrics, Soonchunhyang University, Seoul, Korea. mangazet@hanmail.net
- Publication Type:Case Report
- Keywords:
Lamotrigine;
Antiepileptic hypersensitivity syndrome
- MeSH:
Adolescent;
Anticonvulsants;
Drug Hypersensitivity;
Early Diagnosis;
Exanthema;
Fatal Outcome;
Fever;
Humans;
Infectious Mononucleosis;
Lymphatic Diseases;
Mucocutaneous Lymph Node Syndrome;
Triazines
- From:Korean Journal of Pediatrics
2009;52(3):389-391
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antiepileptic drug hypersensitivity syndrome (AHS), a delayed immunological reaction, is a relatively rare side effect of antiepileptic drugs and is usually overlooked. An array of symptoms can occur one to eight weeks after treatment with an antiepileptic drug. Symptoms may be as simple as a fever, skin rash, or lymphadenopathy, but may eventually involve internal organs and cause fatal outcomes. Additionally, because the symptoms resemble the features of various arrays of diseases and the reported mortality rate is approximately 10%, the importance of early diagnosis and ability to differentiate AHS from other diseases cannot be overemphasized. We report a case of a 14-year-old girl with AHS caused by lamotrigine, which mimicked atypical Kawasaki disease and infectious mononucleosis.
