In Vitro Release of Evening Primrose Oil Microspheres
- VernacularTitle:月见草油微球的体外释放度研究
- Author:
Hong XUE
;
Jianpeng GUO
- Publication Type:Journal Article
- Keywords:
Evening primrose oil;
Microspheres;
UV spectrophotometry;
Release rate
- From:
China Pharmacy
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the release characteristics of Evening primrose oil microspheres in vitro. METHODS:UV spectrophotometry was adopted to determine the accumulated release of microspheres under different media,and the drug release behaviors in vitro were fitted using zero-order,first-order and Higuchi equations. RESULTS:The accumulated release of microspheres in the gastrointestinal liquid (within 6 h) was up to(92.84?0.35)%;under the media of artificial gastric juice,the release of drug conformed to Higuchi equation:Q=5.941t1/2—11.083(r=0.991 7); under the media of artificial intestinal juice,the release of drug was in line with first-rate equation:ln(100—Q)=—0.487 4t+4.588(r=0.996 4). CONCLUSION:This method is simple,accurate and reproducible,and it can be used for the determination of the release rate of the Evening primrose oil microspheres.
