Effect of Breviscapine Injection on the Expression of GFAP and NOS in Rats with Cerebral Ischemia-Reperfusion Injury
- VernacularTitle:灯盏花素对大鼠脑缺血再灌注损伤后胶质原纤维酸性蛋白和NOS的影响
- Author:
Qunhua YANG
;
Xingsan TANG
- Publication Type:Journal Article
- Keywords:
Breviscapine;
Cerebral ischemia-reperfusion injury;
Glial fibrillary acidic protein;
Nitric oxide synthase
- From:
China Pharmacy
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of breviscapine injection on glial fibrillary acidic protein (GFAP) and nitricoxide synthase (NOS) in rats with ischemical reperfusion(I-R)injury. METHODS:The rats were divided into 5 groups:sham group,I-R group,MgSO4 group,breviscapine low dose group and high dose group. Cerebral I-R injury model was established with suture method.The effect of breviscapine injection on GFAP and NOS were evaluated. RESULTS:In ischemia-reperfusion group compared with the sham group,the GFAP staining was strongly positive,serum NOS and inducible NOS (iNOS) activity were significantly enhanced(P
