The changes of GAP-43 expression in spiral ganglion after exposed to noise
- VernacularTitle:噪声性聋小鼠耳蜗螺旋神经节生长相关蛋白-43变化
- Author:
Yin XIA
;
Haishan LONG
;
Shusheng GONG
;
Li LEI
;
Juanjuan FENG
;
Erzhong FAN
;
Ying LI
;
Qing ZHAO
;
Demin HAN
- Publication Type:Journal Article
- Keywords:
Mice;
Animal;
Experimentation;
Noise;
Cochlea;
Wounds and Injuries;
Spiral Ganglion
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To understand the synaptic remodel in inner ear after hearing injury by investigating growth associated protein 43(GAP-43) expression in the inner ear hair cells after exposed Kangmin mice to neural injury noise stimulation to induce permanent threshold shift(PTS) or temporary threshold shift(TTS).METHODS To compare the expressions of GAP-43 of NMDAR signal pathway during neural injury stimulation by immunocytochemistry.RESULTS The sustained GAP-43 increase occurs after 7d and 14d of PTS group,and there is not remarkable difference between them.Compared with normal control,the change is not significant in TTS group.CONCLUSION The increase of GAP-43 in spiral ganglion after 7d trauma reveals the synaptic remodel in inner ear.
