Pharmacokinetics of Glutathione by IV in Beagle Dogs
- VernacularTitle:Beagle犬静脉注射谷胱甘肽的药动学研究
- Author:
Chunmei PU
- Publication Type:Journal Article
- Keywords:
Glutathione;
Dogs;
Intraveneous injection;
HPLC;
Pharmacokinetics
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate pharmacokinetic parameters of glutathione( GSH )after intraveneous injection(iv) in dogs. METHODS: A single dose of 40 mg?kg-1 was given to 12 Beagle dogs by iv,their plasma blood sample in different times were collected and concentrations of GSH were detected by HPLC,then the pharmacokinetic parameters were calculated using 3p97 software program. RESULTS: The concentration-time curves of GSH with iv fitted to two-conpartment model. The main pharmacokinetic parameters including t1/2?、t1/2?、V(c)、CL(s)、AUC0～t were(2.32?1.26) min,(16.03?6.58) min,(1.13?0.54) L?kg-1,(0.080?0.027) L?min-1 and (546.69?189.45) ?g?h?mL-1,respectively. CONCLUSION: GSH in circulatory system of dogs after iv has short retention time and quick elimination.
