Preparation and Drug Release Characteristics in Vitro of Norcantharidin Sustained-release Tablet
- VernacularTitle:去甲斑蝥素缓释片的处方优化及其体外释药特性研究
- Author:
Yaohua GU
- Publication Type:Journal Article
- Keywords:
Norcantharidin;
Sustained-release tablet;
Formulation optimization
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formulation of norcantharidin sustained-release tablet and investigate its in vitro release characteristics. METHODS: The tablet was prepared by using hydroxy-propyl methyl cellulose (HPMC) as the matrix material. The formulation of the tablet was optimized with the amount of HPMC (A),the amount of lactose (B),the concentration of ethanol (C) and the amount of ethanol (D) as factors and with the comprehensive scores of the in vitro release rate as index. Meanwhile,the in vitro release characteristics of the optimized tablets were investigated. RESULTS: The optimal formulation of the tablet was as follows: A=12 g,B=1.5 g,C=90%,D=10 mL. At 2,6 and 12 h the cumulative release rates of the tablet reached (30.63?1.03)%,(51.70?1.51)% and (89.25?1.04)%,respectively. The mechanism for the drug release was the joint action of diffusion and bulk erosion. CONCLUSION: The optimized norcantharidin sustained-release tablet is up to the expected sustained-release efficacy.
