Lymphocyte Subsets in Patients with Hepatitis B Virus Associated Glomerulonephritis.
- Author:
Kook Hwan OH
1
;
Cu Rie AHN
;
Jee Eun OH
;
Yon Su KIM
;
Jin Suk HAN
;
Sung Gwon KIM
;
Myung Hee PARK
;
Jung Sang LEE
;
Jung Sik PARK
;
Jong Ho LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Hepatitis B virus;
Glomerulonephritis;
Lymphocyte;
CD4 cell;
CD8 cell
- MeSH:
Antigen-Antibody Complex;
B-Lymphocytes;
Flow Cytometry;
Glomerulonephritis*;
Glomerulonephritis, Membranoproliferative;
Hepatitis B virus*;
Hepatitis B*;
Hepatitis*;
Humans;
Immunity, Cellular;
Killer Cells, Natural;
Lymphocyte Activation;
Lymphocyte Subsets*;
Lymphocytes*;
Male;
Nephrotic Syndrome
- From:Korean Journal of Nephrology
1998;17(3):407-415
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Immune complex formation has been recently emphasized as an important pathogenetic mechanism of hepatitis B virus associated glomerulonephritis (HBGN), but little are known on the role of cell- mediated immunity in that disease. In this study, we measured lymphocyte subsets of the blood samples from three groups(HBGN group, healthy control group, hepatitis B group without renal disease) by flow cytometry in order to clarify abnormalities in immune regulatory system of HBGN. The results were as follows: 1) To compare between HBGN and healthy control group, the proportion of CD4+ cells were higher for HBGN than for healthy control but that of B lymphocytes were lower for HBGN than for healthy control. Between HBGN and hepatitis B group without renal disease, the proportion of B lymphocytes were higher for HBGN but that of NK cells were lower for HBGN(P<0.05). 2) To compare the male data of the three groups, the percentage of CD4+ cells in HBGN group were higher and the percentage of B lymphocytes were lower than healthy control. Between HBGN group and hepatitis B group without renal disease, no significant difference were noted in CD4+ cells, CD8+ cells, B lymphocytes, NK cells and CD4/CD8 ratio (P<0.05). 3) HBGN patients with membraneous nephropathy (MN) showed higher proportion of CD4+ cells than those with membranoproliferative glomerulonephritis (MPGN)(P<0.05). But, no difference was observed between HBGN patients with and without nephrotic syndrome. Nor between HBGN patients with and without HBe antigenemia. In conclusion, above result implies the pathogenetic role of cell-mediated immunity in HBGN. Analysis of lymphocyte subsets for each stage of HBGN, together with the assay of lymphocyte activation markers is required in the future.
