Effect of laryngopharyngeal reflux on premalignant lesion and cancer of the larynx
- VernacularTitle:咽喉反流及胃食管反流在喉癌前病变及喉癌发生中的作用
- Author:
Lihong ZHANG
;
Hongwei ZHENG
;
Lisheng YU
;
Guijian FENG
- Publication Type:Journal Article
- Keywords:
laryngopharyngeal reflux disease;
24-hour dual probe pH monitoring;
Precancerous Conditions;
Carcinoma,Squamous Cell
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the effect of laryngopharyngeal and gastroesophageal reflux on the development of the laryngeal precancerous lesion and cancer.METHODS Twelve patients with vocal fold precancerous lesions and one patient with laryngeal cancer proved pathologically underwent 24-hour dual probe pH monitoring.All patients had been operated on and follow-up.RESULTS Seven of 13 patients(53.85%)showed positive pH monitoring in laryngopharynx,8 of 13(61.53%)patients showed positive pH monitoring in esophagus.Positive pH monitoring in both sites was found in 6 patients(46.15%).Among 7 patients with laryngopharyngeal reflux and 8 patients with gastroesophageal reflux,positive RSI was found in 5 cases and positive RFS was found in 6 cases.CONCLUSION The laryngopharyngeal reflux may be a risk factor in the development of the laryngeal precancerous lesion laryngeal cancer.
