Effect of Benazepril and Candesartan Combination for Treatment of Hypertension With Microalbuminuria
- VernacularTitle:坎地沙坦与苯那普利联用治疗高血压伴微量白蛋白尿患者的临床观察
- Author:
Xiaofeng CHENG
- Publication Type:Journal Article
- Keywords:
Benazepril;
Candesartan;
Hypertension;
Microalbuminuria;
Endothelin;
Nitrogen monoxide
- From:
Chinese Circulation Journal
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effect between benazepril and candesartan combination and single medication in either one of them for treatment of hypertension-combined with microalbuminuria(MCA). Methods:A total of 95 patients were divided into three groups.Benazepril group(n=31),patients were treated with Benazepril 10～20 mg/day;Candesartan group(n=32),patients were treated with Candesartan 4～8 mg/day;and Combination group (n=32),patients were treated with benazepril 10 mg/day and candesartan 4 mg/day.The medication lasted for 8 weeks.Blood pressure(BP),plasma urinary albumin and creatinine ratio(A/C),endothelin-1(ET-1),nitrogen monoxide(NO)and potassium were examined and compared before and after the medication respectively. Results:The levels of BP,plasma A/C and ET-1 were decrease and NO was increased in all three groups(P0.05,respectively). Conclusion:Effect of benazepril and candesartan combination in patients with hypertension-combined microalbuminuria was better than single medication in either benazepril or candesartan.
