Correlation Between C-erbB-2 and Angiogenesis and Its Clinical Significance in Breast Cancer
- VernacularTitle:乳腺癌C-erbB-2与肿瘤血管生成的关系及其临床意义
- Author:
Xia ZHU
;
Li YANG
;
Li RAN
- Publication Type:Journal Article
- Keywords:
Breast tumor;
C-erbB-2;
Vascular endothelial growth factor;
Microvessel density
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the correlation between C-erbB-2 and angiogenesis of breast cancer and its clinical significance.METHODS: The expression of C-erbB-2,VEGF(vascular endothelial growth factor) and MVD(microvessel density) in breast cancer tissues were detected by two-step immunohistochemical method.RESULTS: For the 50 breast cancer specimens,the positive rate was 44 %(22/50) for C-erbB-2 vs.64%(32/50) for VEGF,and the MVD value was 25.96?11.59.The positive expression rates of C-erbB-2 and VEGF and MVD value in patients with lymph node metastasis of breast cancer were all higher than in those without lymph node metastasis of breast cancer(P0.05).C-erbB-2 expression was positively correlated with VEGF expression(P
