Derma Safety of Miconazole and Chloramphenicol Cream for Guinea Pigs
- VernacularTitle:咪康唑氯霉素乳膏对豚鼠皮肤的安全性评价
- Author:
Junyan YANG
- Publication Type:Journal Article
- Keywords:
Miconazole and chloramphenicol cream;
Safety evaluation;
Acute toxicity test;
Sensitivity test;
Irritation test
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the derma safety of miconazole and chloramphenicol cream (MCC) for Guinea pigs.METHODS:Blank matrix,positive sensitizing agent (2,4-dinitro-chlorobenzene) and MCC (high dose and low dose) were applied on normal or damaged areas of the unhairing backs of Guinea pigs to conduct acute toxicity test,sensitivity test and irritation test,respectively.RESULTS:MCC caused no acute toxicity when applied on the skin of Guinea pigs,nor skin/systemic hypersensitive reaction was noted after repeated sensitization.Single or multiple dosing of MCC caused no irritation on normal skin of Guinea pigs but caused mild irritation on damaged skin which disappeared after 48 h or 72 h.CONCLUSION:MCC has good dermo safety for Guinea pigs.
