Tissue Distribution of Bifendate Solid Lipid Nanoparticles in Mice
- VernacularTitle:联苯双酯固体脂质纳米粒在小鼠体内的组织分布研究
- Author:
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Bifendate;
Solid lipid nanoparticles;
Mice;
Tissue distribution;
Liver-targeted
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the tissue distribution and liver-targeting activity of bifendate solid lipid nanoparticles (DDB-SLN) in mice.METHODS:A total of 60 mice were injected with DDB-SLN or DDB solution (DDBS) with DDB dosage at 20 mg?kg-1.Sampling was scheduled at 0.083,0.25,1,3 and 5 hours,and HPLC was employed to determine and compute the concentrations of DDB in plasma,heart,liver,spleen,lung,kidney and brain as well as the Drug Targeting Index (DTI) and the Drug Selecting Index (DSI) of DDB-SLN on DDBS.RESUTLS:The DDB concentrations in liver were the highest for both groups.At 0.25,1,3 and 5 h,the DDB concentrations in liver in DDB-SLN group were 1.15,3.04,2.72 and 3.62 times those in DDBS group.The DTI of DDB-SLN were 1.151,3.038,2.720 and 3.622,respectively and the DSI were 3.269,7.891,5.948 and 7.759,respectively.CONCLUSION:As compared with DDBS,DDB-SLN is a more potent liver-targeting drug.
