Distribution of Paeonol in Plasma and Brain Tissue of Mice
- VernacularTitle:丹皮酚在小鼠血浆和脑组织中的分布研究
- Author:
Qun CHEN
- Publication Type:Journal Article
- Keywords:
Paeonol;
Plasma;
Brain tissue;
Pharmacokinetic parameters
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the distribution characteristics of paeonol in the plasma and brain tissue of mice.METHODS: The concentrations of paeonol in the plasma and brain tissue of mice were determined by GC-MS and the pharmacokinetic parameters of paeonol calculated with 3P97 software were compared and evaluated.RESULTS: The main pharmacokinetic parameters of paeonol in the plasma and the brain were as follows: Ka:(99.3 h-1 vs 18.22 h-1);t1/2?:(0.04 h vs 0.05 h);t1/2?:(3.95 h vs 71.23 h);t1/2ka:(0.01 h vs 0.04 h);Cmax:(4.57 ?g?mL-1 vs 0.51 ?g?g-1);AUC0→t∶2.32 ?g?mL-1?h,1.62 ?g?g-1?h.CONCLUSION: After intragastric administration,paeonol rapidly absorbed by mice and quickly eliminated from plasma,and it had difficulty in passing through the blood-brain barrier but it has long retention time in brain tissue.
