Preparation of Huperzine A Double-layer Sustained Release Tablets and Their in Vitro Release Characteristics
- VernacularTitle:石杉碱甲双层缓释片的研制及体外释药研究
- Author:
Hongzu ZHOU
- Publication Type:Journal Article
- Keywords:
Huperzine A;
Double-layer tablets;
Uniform design;
In vitro release
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the preparation of Huperzine-A double-layer sustained release tablets and their in vitro release characteristics.METHODS: With HPMC K4M as matrix and lactose as diluting agent for the sustained release layer,and with starch-calcium carbonate as diluting agent and sodium carboxymethyl starch as disintegrating agent for the fast release layer to prepare the double-layer tablets by compression,with the release rate of the compressed tablets determined by HPLC.RESULTS: The fast release layer of the prepared Huperzine-A double-layer tablets disintegrated within 1～2 min and appeared as fine powder,meeting the requirement;the release curve of the sustained release layer of the tablets was in line with Higuchi equation and maintained a sustained release of 12 hours.CONCLUSION: The prepared Huperzine-A double-layer tables achieved the goal of both immediate release and sustained release.
