Compatible Stability of Pazufloxacin Mesilate for Injection with Three Kinds of Hemostatics in Sodium Chloride Injection
- VernacularTitle:注射用甲磺酸帕珠沙星与3种止血药在氯化钠注射液中配伍的稳定性考察
- Author:
Hua WU
- Publication Type:Journal Article
- Keywords:
Pazufloxacin;
Hemostatics;
Mixing;
Stability
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study compatible stability of pazufloxacin mesilate for injection with three kinds of hemostatics in sodium chloride injection.METHODS:The changes of the mixtures in appearance,pH values,insoluble particles and the content of pazufloxacin mesilate within 8 hours after mixing of pazufloxacin injection with etamsylate,Vitamin K1 or aminomethylbenzoic at 25 ℃ under natural illumination in a simulated clinical common concentration were followed.RESULTS:There were no significant change in the appearance,pH value and the content of pazufloxacin mesilate within 8 hours after mixing of pazufloxacin mesilate for injection with aminomethylbenzoic injection or etamsylate injection;when mixed with Vitamin K1,there were no significant change in the appearance,pH and the content of pazufloxacin mesilate within 2 hours,but the insoluble particles was found to be unqualified after 1 hour of mixing,and white precipitate appeared after 4 hours and the content of pazufloxacin mesilate decreased to some degree.CONCLUSION:The mixture of pazufloxacin mesilate for injection and etamsylate or aminomethylbenzoic was stable within 8 hours at room temperature.The mixing of pazufloxacin mesilate for injection with Vitamin K1 should be conducted with caution.
