Effect of Gongqing Granule on Expression of Apoptosis Gene in Chorionic Villi and Decidua after Medical Abortion in Early Pregnancy
- VernacularTitle:宫清颗粒对早孕妇女药物流产后绒毛及蜕膜凋亡基因的影响
- Author:
Lijuan ZHANG
;
Ruifen LIU
- Publication Type:Journal Article
- Keywords:
Gongqing Granule(Granule for Clearing the Uterus);
Medical abortion;
Apoptosis;
Apoptosis gene
- From:
Journal of Traditional Chinese Medicine
1993;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible mechanism of Gongqing Granule(Granule for Clearing the Uterus) on shortening the duration of vaginal bleeding after medical abortion.Methods The 120 unwanted pregnancy women within 49d of intrauterine gestation were randomly divided into three groups.Gongqing Granule combined with mifepristone and misoprostol was administered orally in Group A(treatment group).Qianzhi Capsule combined with mifepristone and misoprostol was administered orally to Group B(control group),and only mifepristone plus misoprostol was administered orally to Group C(blank group).Other 40 women(Group D,induced abortion group),were treated with vacuum aspiration for abortion.Chorionic villi and decidual tissue were collected and expression of Bax and Bcl-2 were detected by immunohistochemical method and Bax mRNA and Bcl-2 mRNA by situ hybridization.Results The expression of Bax,Bcl-2,Bax mRNA and Bcl-2 mRNA was found in all groups.The expression of Bax and Bax mRNA in the treatment group was higher than those in the control group,then the blank group,and then induced abortion group.While the expression of Bcl-2 and Bcl-2 mRNA of the treatment group was lower than those in the control group,then the blank group,and then induced abortion group(P
