Alteration of lymphocyte P-gp expression level and function in liver transplant recipient
- VernacularTitle:肝移植患者术后淋巴细胞P-gp水平及其功能改变的研究
- Author:
Shenghua HAO
;
Wenpeng HUANG
;
Zufa HUANG
- Publication Type:Journal Article
- Keywords:
Liver Transplantation;
Lymphocyte;
P-gp;
Immunosuppressive Agents
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alteration of lymphocyte P-gp expression level and function in liver transplant recipient and its effect on immunosuppressive therapy.Methods Using flow cytometry,the level of lymphocyte P-gp and analyzed the P-gp function in 53 cases of liver transplant recipieints was observed.Results Among 53 cases,the preoperative mean level of lymphocyte P-gp was(10.34?4.0)%,P-gp level began to increase in the 1st month postoperatively(17.8?8.0)%,peaked in the 3rd month(27.5?13.3)%,and then was stable at this level thereafter.There were no significantly difference between different sex of age group.But the P-gp level in CD+4T cells was significantly higher than that in CD+8T cells and B cells,RH123test showed that high P-gp expression of lymphocyte enhanced its transport activity of medical agents,and decreased the intracellular accumulation of drug more significantly than that of low P-gp expression(P
