Effect of cyclooxygenase-2 on hepatic injury and metabolism in rats with sepsis
- VernacularTitle:COX-2对脓毒症大鼠肝损伤和代谢的影响
- Author:
Bin LI
;
Bin SHI
;
Liping LIU
;
Yumin LI
- Publication Type:Journal Article
- Keywords:
Liver/pathol;
Sepsis;
Cyclooxygenase-2;
NS-398;
Metabolism
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cyclooxygenase2 in hepatic inflammatory reaction of rats with sepsis and its effect on metabolism.Methods Fifty-four Wistar rats were randomly divided into 3 groups:Sham(A)group,sepsis model(B)group,and NS398 intervention(C)group.The rats were subjected to cecal ligation and puncture(CLP)for sepsis model or sham operation.RT-PCR was used to determine COX-2 mRNA expression,serum prealbumin(PA)and transferrin(TF)by radioimmunity.At the same time,ALT,AST,albumin determination and liver pathological changes were determined.Results(1)The expression of COX-2 mRNA was low in A group,higher in B and C groups,and higher in B than C group at each time period(P