Galectin-3 expression in normal and LPS-stimulated genital system of female mouse
- VernacularTitle:Galectin-3在雌性小鼠生殖系统中的表达及脂多糖的影响
- Author:
Yanhong YU
;
Shanpei PAN
;
Qixuan XIE
;
Yiqing GUAN
;
Dan HUANG
- Publication Type:Journal Article
- Keywords:
Galectin-3;
Genital tract;
Lipopolysaccharides
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the expressions of galectin-3 and the possible anti-infectious function in genital tract of female mouse. METHODS:The expressions of galectin-3 mRNA in different reproductive tissues were analyzed by RT-PCR. The mouse model of genital tract infection was constructed by injection of LPS and Freunds adjuvant incomplete into the vaginal mucous. The expression pattern of galectin-3 protein was detected by immunohistochemistry. RESULTS:The expression of galectin-3 mRNA was detected in the uterus,vagina,oviduct and ovary of normal adult mouse. The galectin-3 protein was expressed in the genital tract mucous of epithelial cell surface and uterine gland. After stimulation with LPS,the expression of galectin-3 protein was significantly up-regulated compared to normal control and adjuvant control (P
