Comparison of Dispersibility Between Plasdone K30 and Plasdone S630 in Nimesulide Dispersible Tablets
- VernacularTitle:聚维酮K30、S630对尼美舒利分散片分散性能的影响
- Author:
Gangtao ZHAO
;
Lin XU
;
Yingzheng ZHAO
;
Jingfeng XU
- Publication Type:Journal Article
- Keywords:
Plasdone K30;
Plasdone S630;
Nimesulide dispersible tablets;
Adhesive
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To compare dispersibility between two kinds of plasdone used as the hydrophilic adhesive in nimesulide dispersible tablets.METHODS: Nimesulide dispersible tablets were prepared with Plasdone S630 and Plasdone K30 as the hydrophilic adhesive respectively which were dissolved in 5% alcohol solution or 5% water solution.By friability,hardness and dispersibility tests,the influence of S630 and K30 in quality of nimesulide dispersible tablets were observed.RESULTS: Plasdone S630 alcohol solution or aqueous solution showed same or better results in friability,hardness and dispersibility compared with Plasdone K30 alcohol solution or aqueous solution.CONCLUSION: Plasdone S630 could be used as a alternate of K30 for hydrophilic adhesive in dispersible tablets.
