Preparation and in Vitro Yinxingye Extract Pellets
- VernacularTitle:银杏叶提取物微丸的制备及其释放度研究
- Author:
Liandong HU
;
Zhaoliang LUO
;
Qianbin XING
;
Ci LIU
;
Zhiqin LIU
;
Chuang SHANG
- Publication Type:Journal Article
- Keywords:
Yinxingye extract;
Sustained-release;
Pellets;
Coating
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Yinxingye extract pellets and study its in vitro drug release rate.METHODS:The Yinxingye extract were coated with 3 coating materials(opadryⅡ,Eudragit L30D-55 and Eudragit S 100,respectively)to be prepared into pallets by centrifugalized palletizing method;and the 3 different coated pallets were prepared into mixed pallets in an pre-designed ratio.The in vitro release of the 3 coated pallets and the mixed-coated pallets were determined by changing the pH-gradient of media(0.1 mol?L-1 hydrochloric acid,pH 5.8 PBS,pH 7.2 PBS).RESULTS:The pallets coated with 3 different coating materials released quickly in 0.1 mol?L-1 hydrochloric acid,pH 5.8 PBS and pH 7.2 PBS,and the pellets with mixed coating materials had a sustained release until a complete release within about 8 h in pH gradient-changed media.CONCLUSION:The preparation process is feasible and provides theoretic basis for industrial production.
