Bioavailability of Oral Drugs Following Chinese Materia Medica's Action on CYP3A4 and P-gp in Intestine
- VernacularTitle:重视中药作用于肠道CYP3A4、P-gp后对口服药物生物利用度的影响
- Author:
Rong TAN
;
Zhichang ZHENG
;
Weidong LI
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
Chemical composition of Chinese materia medica;
CYP3A4;
P-gp;
Bioavailability
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To promote rational combined use of Chinese Chinese materia medica with western medicines.METHODS:The mechanisms for Chinese materia medica and its chemical compositions to change the bioavailability of orally taken substrates by its inhibiting or inducing intestinal CYP3A4 and P-gp were summarized,and which were analyzed by combining the literature.RESULTS:Fructus Schisandrae,Radix Angelicae Dahuricae,Radix Angelicae Sinensis,Rutaecarpine,Ginkgolide A etc could inhibit or induce the CYP3A4 enzyme;Radix Scutellariae,common St.Johnwort herb with root,Naringenin,Hypericin etc could inhibit or induce P-gp.The change of the parameters of the bioavailability of substrate drugs caused by Chinese materia medica and its chemical compositions through acting on intestinal CYP3A4 and P-gp could influence the drug safety and efficacy.CONCLUSION:Clinicians and pharmacists should attach importance to the drug interactions in the concomitant use of Chinese traditional medicines and western drugs so as to promote rational drug use.
