Efficacy of Piperacillin/Tazobactam versus Ciprofloxacin plus Metronidazole for Complicated Intraabdominal Infection
- VernacularTitle:哌拉西林/他唑巴坦单用与环丙沙星联合甲硝唑治疗复杂腹腔内感染的疗效对比观察
- Author:
Lijuan LIU
- Publication Type:Journal Article
- Keywords:
Complicated intraabdominal infections;
Piperacillin/Tazobactam;
Ciprofloxacin;
Metronidazole
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy of Piperacillin/Tazobactam versus Ciprofloxacin plus Metronidazole for complicated intraabdominal infection. METHODS: 192 patients whose bacterial culture test on intraoperative-resected samples indicated growth of at least one pathogen were treated with Piperacillin/Tazobactam versus Ciprofloxacin plus Metronidazole for complicated intraabdominal infection. The drug resistance of the pathogens isolated form intraoperative-resected samples and the parameters including the clinical effective rate etc were compared between the two groups excluding the resistant cases. RESULTS: 85 case received Piperacillin/Tazobactam versus 107 cases received Ciprofloxacin plus Metronidazole,and the resistance rates of the pathogens isolated from the intraoperative-resected samples were 5.9% (5/85) and 21.5% (23/107),respectively. The clinical effective rates in the two groups excluding the resistant cases were 92.5% (74/80) and 77.4%(65/84),respectively,showing significant difference (P
