Analysis of Adverse Drug Reactions Induced by Anti-epileptic Medicines in Intensive Care Unit of Neurology
- VernacularTitle:神经内科重症监护病房抗癫痫药引发药品不良反应报告分析
- Author:
Jianping DING
- Publication Type:Journal Article
- Keywords:
Dept. of neurology;
Intensive care unit;
Anti-epileptic medicine;
Adverse drug reactions
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the adverse drug reactions(ADR) caused by anti-epileptic medicines used for patients in the Neurological Intensive Care Unit (ICU) for reference of rational use of anti-epileptic medicines. METHODS: The ADR induced by anti-epileptic drugs between May 2006 and Nov. 2007 in neurological ICU patients with secondary epilepsy were analyzed retrospectively. RESULTS: A total of 24 ADR cases (24/50,47.06%) induced by anti-epileptic drugs were reported from Neurological Intensive Care Unit(ICU). The ADR were mainly induced by carbamazepine,valproate sodium,oxcarbazepine and phenobarbital,and the ADR mainly appeared as skin rash,hypolekocytosis,hepatic dysfunction and hyponatremia etc,but all cured after prompt treatment. CONCLUSION: The risk/efficiency ratio should be considered in clinical use of anti-epileptic drugs,and those drugs showing remarkable efficacy and few adverse reactions should be used preferably to reduce the damage to patients caused by ADR.
