Effect of Electro-acupuncture on Activation of Glial Cells and Neuronic Ultrastructure in Hippocampus of Alzheimer' s Rats
- VernacularTitle:电针对阿尔茨海默病大鼠海马区胶质细胞活化及神经元超微结构的影响
- Author:
Shuxiu ZHU
;
Guojie SUN
- Publication Type:Journal Article
- Keywords:
Electro-acupuncture;
Alzheimer disease;
Glial cells;
Ultrastructure
- From:
Journal of Traditional Chinese Medicine
1993;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electropuncture on activation of glial cells and neuronic ultrastructure in hippocampus of Alzheimer disease(AD) rats,and to investigate its protective effect on neuron.Methods AD rat model was established by microinjection of amyloid-beta protein(A?1-40) into the Meynert nucleus of rats,then randomly divided into normal group,sham operation group,model group and electropuncture group,14 rats in each.Electro-acupuncture was given at "baihui(DU 20)","taixi(KI 3)" and "zusanli(ST 36)"in the electro-acupuncture group;activation of glial cells in hippocampus was determined by immunohistochemistry,and ultrastructure of neurons was observed under transmission electron microscopy in all group of rats.Results A great number of glial cells were activated in model group with increase of the number,nerve cell degeneration,endoplasmic reticulum to expand,and chondriosome to swell.After treatment of electro-acupuncture,the number of activated glial cells decreased as compared with model group,and the ultrastructure returned to almost normal.Conclusions Electro-acupuncture treatment can decrease the number of activated glial cells of AD rats so as to protect the neurons.
