Optimization of the Formulation of Alprazolam Sustained-release Tablet and Study on Its Release in Vitro Characteristics
- VernacularTitle:阿普唑仑缓释片的处方筛选及体外释放度考察
- Author:
Ruiting ZHAO
- Publication Type:Journal Article
- Keywords:
Alprazolam;
Sustained-release tablets;
Formulation optimization;
Release rate in vitro
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formulation of alprazolam sustained-release tablet and investigate its in vitro release profile.METHODS:Orthogonal experiment was carried out to optimize the formulation of alprazolam sustained-release tablet with the matching percentages of hydroxypropyl methyl cellulose(HPMC),ethyl cellulose and lactose and the specification of the HPMC as factors and with the in vitro release rate as index.The in vitro release rate of the optimized preparation was investigated as well.RESULTS:The optimal formulation of alprazolam sustained-release tablet as follows:the matching percentages of HPMC,ethyl cellulose and lactose were 30%,4% and 15%,respectively,and the specification of the HPMC was K4M.The alprazolam sustained-release tablet prepared in this optimized formulation achieved a sustained release of 24 h with its release profile in line with the Higuchi equation.CONCLUSION:The optimized alprazolam sustained-release tablet is reasonable in formulation and characterized by sustained release.
