Glimeiride Tablets vs. Glimeiride Dropping Pills in Dissolution in Vitro
- VernacularTitle:格列美脲片剂与滴丸体外溶出度比较
- Author:
Shengda ZHANG
;
Jiewei DING
;
Xiaomei WANG
- Publication Type:Journal Article
- Keywords:
Glimepiride;
Tablets;
Dropping pills;
Dissolution
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the vitro dissolution between glimepiride tablets and glimepiride dropping pills.METHODS:In vitro dissolution test was conducted in accordance with the related methods specified in Chinese Pharmacopeia(2005 Edition)with the content of glimepiride determined by UV spectrophotometry.The accumulative dissolution percentages of the two formulations were computed respectively.The dissolution parameters(T50,Td,m,r)were fitted using Weibull equation and the data about the accumulative dissolution percentage were analyzed.RESULTS:There were significant differences between glimepiride tablets and glimepiride dropping pills in dissolution rate(18.70% vs.40.25% at 5 min and 90.32%vs.99.96% at 45 min,P
